It is starting to look like a few different factors are involved instead of one or two, for severe anxiety. It's like Ernst said with ADHD, there is not just one common astrological factor responsible.
Saturn was definitely involved for me looking back, not just in the Virgo return, but it was also transiting natal Ketu during the earlier series, on the Aqu/Pis border.
The most panic-triggering event that probably started it all, and that I had flash-backs to, had Rahu right on on top of lagna point within the degree, Saturn on top of natal Ketu, almost exact degree, Moon on top of natal db Mercury (again, within the degree), Pluto within a few degrees of Moon in Sco, and Neptune and Uranus were both closely conjunct each other, within the same degree, in transit. And Mars was rising and within several degrees of natal Rahu.
one of the indicators for anxiety is a Mars/Saturn conjunction
Regular physical exercise and strength activities might help with Mars/Saturn, but may be injury prone if someone throws them self into it too hard at first, especially if done with a competitive desperate streak.